Saturday, February 22, 2014

Gabapentin - The miracle drug

Gabapentin

   

Gabapentin was initially synthesized to mimic the chemical structure of the neurotransmitter gamma-aminobutyric acid (GABA), but is not believed to act on the same brain receptors. The mechanism of action that leads to its rapid analgesic effect is simply unknown. 

   So now that you know a little bit about Gabapentin let me tell you how this drug can save you from the worst part of opiate withdrawals (being the first three days) Gabapentin when taken at high doses (1800 mg - 3600 mg) will completely take away the discomfort of withdrawals. The only problem with the drug is you build up a tolerance fast. On the first day start with 1800 mg, the second day 2400 mg and on the third day 3600 mg. After the third day gabapentin will do you no good. Not only does it help with withdrawals but it makes you feel good, more social, lights seem brighter, basically it's a good time. Gabapentin is prescribed a lot for a lot of off label uses (uses not approved by the FDA) originally gabapentin was prescribed for seizures and later for nerve pain but is now prescribed for everything from bi-polar disorder to migraine relief. Doctors have no problem prescribing this drug because it is non-narcotic so if you ask your doctor for it to help with withdrawals he'll probably give it to you or you could always tell him your having migraines. Other than that you might very well know someone that is already prescribed it and get some from them (taking other peoples meds is illegal and you do it at your own risk) 

Friday, February 21, 2014

Kratom & Phenibut


KRATOM Another great way to beat opiate withdrawals is with kratom. Kratom behaves as a μ-opioid receptor agonist like morphine but doesn't depress your respiratory system like Opiates. I've used kratom extensively myself, both to hold off opiate withdrawals and as a work-aid / pain reliever. Many people will make a tea out of the kratom but take it from me it tastes terrible. I've found the best way to take kratom is in capsules, you can buy capsules of kratom online or at headshops but this is very expensive. The most economical way to purchase kratom is to buy powdered kratom online and buy empty capsules either online or from your local health food store and cap them up yourself. I recommend buying the '00' size capsules as you'll have to take less of them at a time. a normal dose is going to be four '0' size capsules or two '00' capsules. Not only will kratom stop withdrawals in it's tracks it also will make you feel pretty damn good. Kratom can be addicting but the withdrawals from kratom are much less severe and it takes quite a bit longer to get to the point of having withdrawal symptoms.
Oral Kratom Dosages (dried leaf)
Enhanced (Extract Added)
Threshold1 gram
Light1-2 grams
Common2-3 grams
Strong3-6 grams

Oral Kratom Dosages (dried leaf)
Super Grade
Threshold1-2 grams
Light2-4 grams
Common3-5 grams
Strong4-8 grams

Oral Kratom Dosages (dried leaf)
Premium Grade
Threshold2-4 grams
Light3-5 grams
Common4-10 grams
Strong8-15 grams

Oral Kratom Dosages (dried leaf)
Low Potency (very uncommon as of 2008)
Threshold3-7 grams
Light5-10 grams
Common10-20 grams
Strong20-50 grams

Onset : 5-15 minutes
Duration : 2-5 hours
Normal After Effects : 3-6 hours


 Phenibut In chemical structure, phenibut is a phenyl derivative of GABA. Although the calming action is similar to other GABA agonists, phenibut binds to the GABAB metabotropic receptor, the same site responsible for the sedative effects of baclofen (the para-chloro derivative of phenibut) and γ-hydroxybutyrate (GHB), although GHB also acts at the GHB receptor.[6] There is dispute in the literature about whether or not phenibut binds to the GABAA ionotropic receptor, which is responsible for the actions of the benzodiazepines, barbiturates, z-drugs, and for some of the effects of ethanol. Phenibut is a great substitute for benzo's and can come in really handy if your having trouble with anxiety while coming off opiates. Phenibut has a very calming effect on the body and produces euphoria. Some people say higher doses make them feel like their body is "drunk" without clouding the mind. Phenibut is available online and is completely legal. Phenibut is addictive though, quite a bit more so than kratom and so should only be used on a 2-3 days on / 3 off schedule. If your going through withdrawals right this moment and can't wait for kratom and phenibut to arrive in the mail than refer back to my previous post about the loperamide fix but if you can wait a few days kratom and phenibut are amazing substances that if taken responsibly can help you get past the terrible ordeal of opiate addiction and withdrawals. I find a good dose of phenibut is between 500 - 1000 mg or 1 - 2 size '0' capsules. Capsuling your own phenibut is also the most cost effective method.




Where I buy my Kratom and Phenibut from (The Leaping Leaf)

Monday, September 3, 2012

Loperamide (Opiate) Withdrawal Cure



   Let me just start by saying that I have personally struggled with opiate addiction for over 10+ years now. Everything I include in this blog will be from my own past attempts to survive opiate withdrawals. I am not a doctor and will take no personal responsibility for any harm that may result from people recreating my experiments and methods. That being said let's get right into how to use Loperamide (Imodium) and other OTC items to completely chase away those terrible opiate withdrawals.

  Now as some of you may or may not know Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus of the large intestine; the problem is however that by itself it does not affect the central nervous system because it is unable to cross the Blood Brain Barrier (BBB). To fix this problem you will need the following items.

1. Loperamide (Obviously) 72ct - 2mg generic lope tablets cost $4.98 at my Wal-mart

2. Cimetidine 200ct - generic(Tagamet) 200mg  is $7.12 at wal-mart as well 

3. Jug of grapefruit juice which is about $4.00 (Not from Concentrate) I like to use "Simply" Grapefruit Juice.

4. Tonic Water (This is Optional) 

  Now the reason that we need the Tagamet (Cimetidine), Grapefruit Juice and Tonic water is all to help the Loperamide cross the BBB. Many people, including doctors and pharmacists, don't believe that loperamide can cross the BBB but In fact, loperamide does cross this barrier, although it is immediately pumped back out into non–central nervous system (CNS) circulation by P-glycoprotein. This is where our extra shopping comes in handy. Both Cimetidine and grapefruit juice (also Tonic Water to a much lesser degree) are known to inhibit P-glycoprotein and may thus render the CNS vulnerable to opiate agonism. ( Or in laymen's terms it let's the stuff get absorbed into your brain where you desperately need it) The tonic water is optional because as it does contain quinine, which would be a very useful P-glycoprotein inhibitor, the amount that it contains has been greatly reduced by the FDA. You can use it to make a sparkling drink with your grapefruit juice if you like though.

 Now that we have the science and the shopping list done we can move on to putting this all to use. 

Step 1 - Take 600mg-1g of Cimetidine and wait for 30 mins - 1 hr

Step 2 - Take 20-60 mg of loperamide ( This will very depending on how heavy an opiate user you are, a very light user may be able to take only 10mg of loperamide, while a heavy user might have to take up to 100mg. For a general dose I'd say take 30mg and see how it does for you then increase or decrease the dose as needed.)

Step 3 - Use your Grapefruit juice / Tonic water to wash down your Loperamide. 


  For myself this method will keep away opiate withdrawals for up to 12 hrs with one dose. The price this all works out to is about $20 for three days of living without withdrawals, which is a bargain believe me.