Monday, September 3, 2012
Let me just start by saying that I have personally struggled with opiate addiction for over 10+ years now. Everything I include in this blog will be from my own past attempts to survive opiate withdrawals. I am not a doctor and will take no personal responsibility for any harm that may result from people recreating my experiments and methods. That being said let's get right into how to use Loperamide (Imodium) and other OTC items to completely chase away those terrible opiate withdrawals.
Now as some of you may or may not know Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus of the large intestine; the problem is however that by itself it does not affect the central nervous system because it is unable to cross the Blood Brain Barrier (BBB). To fix this problem you will need the following items.
1. Loperamide (Obviously) 72ct - 2mg generic lope tablets cost $4.98 at my Wal-mart
2. Cimetidine 200ct - generic(Tagamet) 200mg is $7.12 at wal-mart as well
3. Jug of grapefruit juice which is about $4.00 (Not from Concentrate) I like to use "Simply" Grapefruit Juice.
4. Tonic Water (This is Optional)
Now the reason that we need the Tagamet (Cimetidine), Grapefruit Juice and Tonic water is all to help the Loperamide cross the BBB. Many people, including doctors and pharmacists, don't believe that loperamide can cross the BBB but In fact, loperamide does cross this barrier, although it is immediately pumped back out into non–central nervous system (CNS) circulation by P-glycoprotein. This is where our extra shopping comes in handy. Both Cimetidine and grapefruit juice (also Tonic Water to a much lesser degree) are known to inhibit P-glycoprotein and may thus render the CNS vulnerable to opiate agonism. ( Or in laymen's terms it let's the stuff get absorbed into your brain where you desperately need it) The tonic water is optional because as it does contain quinine, which would be a very useful P-glycoprotein inhibitor, the amount that it contains has been greatly reduced by the FDA. You can use it to make a sparkling drink with your grapefruit juice if you like though.
Now that we have the science and the shopping list done we can move on to putting this all to use.
Step 1 - Take 600mg-1g of Cimetidine and wait for 30 mins - 1 hr
Step 2 - Take 20-60 mg of loperamide ( This will very depending on how heavy an opiate user you are, a very light user may be able to take only 10mg of loperamide, while a heavy user might have to take up to 100mg. For a general dose I'd say take 30mg and see how it does for you then increase or decrease the dose as needed.)
Step 3 - Use your Grapefruit juice / Tonic water to wash down your Loperamide.
For myself this method will keep away opiate withdrawals for up to 12 hrs with one dose. The price this all works out to is about $20 for three days of living without withdrawals, which is a bargain believe me.
My next Blog will be on the Wonders of Gabapentin, so stay tuned !